Full Cast — Life in Pieces (2015–2019)

Thomas Sadoski

Matt Short

Dianne Wiest

Joan Short

James Brolin

John Short

Zoe Lister-Jones

Jen

Colin Hanks

Greg Short

Betsy Brandt

Heather Short

Dan Bakkedahl

Tim Hughes

Angelique Cabral

Colleen

Niall Cunningham

Tyler Hughes

Holly J. Barrett

Samantha Hughes

Giselle Eisenberg

Sophia Hughes

Hunter King

Clementine

Ana Sophia Heger

Lark

Randy Schell

Narrator

Ashley Wolff

Jenna

Vivaan Bisoi

Lucas

Fortune Feimster

Dougie

Martin Starr

Oscar

Pam Trotter

Pam / Shannon

Cassidy Naber

Beverly

Martin Mull

Gary Timpkins

Cary Elwes

Professor Sinclair Wilde

Matt Cornett

Ryan

Jordan Peele

Chad

Susan Park

Dr. Sally Hong

Rhys Darby

Teddy

Andrew McKeough

Jayden

Todd Sherry

Clancy

Ann Morgan Guilbert

GiGi

Jerry Lambert

Chase

Tema Louise Sall

Automated Voice (voice) / Toy Potty (voice) / Art Instructor

Joey King

Morgan

Christine Woods

Alex Morandi

Abbey DiGregorio

Dianna Jazzelroy

Gita Reddy

Principal Jennings

Stephnie Weir

Bernadette

Jonathan Marballi

Levi

Taylor Coffman

Helen

Tonita Castro

Tonita

Ken Marino

Will

Bella Shepard

Lexie

Miranda De Meo

Maggie

Oscar Nuñez

Dr. James Changa

Gillian Vigman

Tabitha

Bryan Coffee

Jody

Brad Grunberg

Jerry

Greg Grunberg

Mikey

Richie Cottrell

Keifer / Willy

Jackie Seiden

Diora

JB Smoove

Darryl

Leith M. Burke

Dr. Casey Dia

Russell Peters

Dr. Tak Oh

Angela Malhotra

Nurse Sylvie

Wayne Federman

Dr. Saul Antro

Michael Lanahan

Dr. Nopunn

Mark Beltzman

Max

Andy Buckley

Paul

Teddy Blum

Noble

Ethan James Spitz

George

Gunnar Goldberg

10-Year-Old Tyler / Young Tyler

Bardia Seiri

Corbin

Nick Thune

Finn Jazzelroy

Jade Catta-Preta

Rita

Carla Jimenez

Sherri

Paul Dooley

Mort