Full Cast — Mike & Molly (2010–2016)

Billy Gardell

Mike Biggs

Melissa McCarthy

Molly Flynn

Reno Wilson

Carl McMillan

Swoosie Kurtz

Joyce Flynn

Katy Mixon

Victoria Flynn

Rondi Reed

Margaret 'Peggy' Biggs

Louis Mustillo

Vincent Moranto

Nyambi Nyambi

Samuel

Cleo King

Rosetta 'Grandma' McMillan

David Anthony Higgins

Harry

Holly Robinson Peete

Christina

Reginald VelJohnson

Brother Heywood

Laura Coover

Rebecca

Cheryl Hawker

Lynette

Francis Guinan

Jack Biggs

William Sanderson

Dennis

Brendan Patrick Connor

George

Marianne Muellerleile

Connie

Lamont Thompson

Andre

Susan Sarandon

J.C. Small

Joel Murray

Dr. Jeffries

Juliette Goglia

Frannie DuVall