Full Cast — Pepper Ann (1997–2000)
Kathleen Wilhoite
Pepper Ann (voice)
Danny Cooksey
Milo (voice)
Clea Lewis
Nicky (voice)
April Winchell
Mom (voice)
Pamela Adlon
Moose (voice) / Goose O'Shaunassy (voice)
Jeff Bennett
Craig Bean / Dieter Liederhosen / Bob / Additional Voices (voices) / Dieter Liederhosen / Craig Bean / Shelf McClain (voice) / Dieter Liederhosen / Emit Swink / Shelf McClain (voice) / Craig Bean (voice) / Craig Bean / Pink-Eye Pete / Additional Voices (voice) / Craig Bean +26 more
Kath Soucie
Cissy Rooney (voice) / Additional Voices (voice) / Mail Lady (voice) / Cissy Rooney / Additional Voices (voice) / Mean Girl (voice) / Cissy Rooney / Supermodel Mindy (voice) / Cissy Rooney / Mrs. Little / Grammie Pearson (voice)
Candi Milo
Rose (voice) / Constance Goldman (voice) / Constance Goldman / Deeana / Biana (voice)
Jenna Von Oÿ
Trinket (voice) / Trinket St. Blair (voice)
Tino Insana
Uncle Jo Jo (voice) / Uncle Jojo / Earl (voice) / Additional Voices (voice) / Uncle Jojo (voice)
Susan Tolsky
Aunt Janie (voice) / Aunt Janie Diggety (voice) / Aunt Janie Diggety / Aunt Lanie (voice)
Cree Summer
Tessa & Vanessa James (voice) / Crying Girl (voice) / Tessa James / Vanessa James / Additional Voices (voice) (as Cree Summer-Francks) / Tessa and Vanessa James (voice) / Tessa and Vanessa James / Additional Voices (voice)
Alex Trebek
Paddi Edwards
Vera Groober-Schwarz (voice) / Vera Groober-Schwartz (voice)
Don Lake
Mr. Sherman Finky (voice) / Mr. Sherman Finky / Butler (voice)
Don Adams
Principal Herbert Hickey (voice) / Principal Hickey (voice)
Jess Harnell
Abe (voice) / Male Scientist / Nigel / Mailman (voice) / Additional Voices (voice)
Mark Hamill
Kathy Najimy
Coach Doogan (voice)
Tara Strong
Brenda / Female Scientist (voice) / Brenda (voice)
Jim Cummings
Mr. Roland Carter (voice) / Mr. Roland Carter / Additional Voices (voice)
Kenn Michael
Lamar Abudabe (voice) / Lamar Abu Dabe (voice) / Malik / Lamar Abu Dabe (voice)
Maurice LaMarche
Chuck Pearson / Jeweler (voice) / Chuck Pearson / Menorah / Colonel Delaney (voice) / Chuck Pearson / Frankie / Uncle Harry (voice)
Jodi Benson
Amber O'Malley (voice)
Isabel Sanford
Bernice (voice)
Hedy Burress
Effie Shrugg (voice)
Bebe Neuwirth
Ms. Bladdar (voice) / Ms. Bronte Bladdar (voice)