Full Cast — Samantha Who? (2007–2009)

Christina Applegate

Samantha Newly

Jennifer Esposito

Andrea Belladonna

Kevin Dunn

Howard

Melissa McCarthy

Dena

Tim Russ

Frank

Barry Watson

Todd

Jean Smart

Regina Newly

Rick Hoffman

Chase Chapman

Stephen Rannazzisi

Seth

Billy Zane

Winston Funk

Kiele Sanchez

Chloe

James Tupper

Owen

Joy Osmanski

Tracy

McKinley Freeman

Tony Dane

Eliza Coupe

Willow

Eddie Cibrian

Kevin

Dana Sorman

Jerri

Adam Devine

Tyler

Nakia Burrise

Kerry Hall

Timothy Olyphant

Winston Funk