Full Cast — The Powerpuff Girls (1998–2005)

Cathy Cavadini

Blossom (voice)

Tara Strong

Bubbles (voice)

E. G. Daily

Buttercup (voice)

Tom Kenny

Mayor / Snake / Lil' Arturo / Narrator (voice)

Tom Kane

Professor Utonium / Him / Talking Dog (voice)

Roger L. Jackson

Mojo Jojo (voice)

Jennifer Martin

Ms. Sara Bellum (voice)

Jennifer Hale

Ms. Keane / Princess Morbucks / Sedusa (voice)

Jim Cummings

Fuzzy Lumpkins (voice)

Jeff Bennett

Ace / Grubber / Big Billy (voice)

Chuck McCann

The Amoeba Boys (voice)

Rob Paulsen

Brick / Boomer (voice) / Puppet Pal Mitch (voice) / Dad / Little Utonium / Mr. Anoush / Junior / Schoolboy #1 (voice) / Scientist / Brutus / Government Man #2 (voice) / Major Glory / E-Male (voice)

Julie Nathanson

Science Teacher / Schoolgirl #1 / Young Ms. Bellum (voice) / Robin (voice)

Candi Milo

Newswoman (voice) / Cleaning Woman (voice)

Phil LaMarr

Katanga (voice) / Bouncer / Guvn'r / Big John / Peses Bill (voice)

Kevin Michael Richardson

Alien Leader / Mailman / Government Man #3 (voice) / Shaquille Silverstein / Ya-Man / Announcer (voice)

Phyllis Diller

Mask Scara (voice)

Christine Cavanaugh

Bunny (voice)

June Foray

Madame Argentina (voice)

Greg Eagles

Sandman (voice)